Thrombocytopenia, an important marker of disease activity, was the most frequently observed TTP manifestation. TAK-755 also reduced the incidence of thrombocytopenia by 60%, as compared to plasma-based therapy (for the rate ratio = 0.40 TAK-755/plasma-based therapy with 95% Confidence Interval 0.3 to 0.7). In the pivotal trial, no patient had an acute TTP event while receiving TAK-755 prophylactic treatment. Both acute and subacute TTP events, including TTP-related organ-specific signs and symptoms were evaluated. 1 These studies were designed to evaluate the clinical benefit of TAK-755 in patients with cTTP across multiple clinically relevant endpoints and based on the totality of the evidence provided by efficacy, PK, safety and tolerability data. Acute TTP events have a mortality rate of >90%, if left untreated. Clinical presentation of cTTP lies on a spectrum of severity ranging from severe acute TTP events to chronic, recurring TTP manifestations (e.g., thrombocytopenia, hemolytic activity, headache, abdominal pain). The developers should withdraw this release, go back to 1.8x and only (re)release 2.x when it is fully debugged.OSAKA, Japan & CAMBRIDGE, Mass.-( BUSINESS WIRE)-Takeda ( TSE: 4502/NYSE:TAK) today presented favorable interim results from a global pivotal Phase 3 randomized, controlled, open-label, crossover trial evaluating the safety and efficacy of TAK-755 (recombinant ADAMTS13) replacement therapy for the prophylactic treatment of congenital thrombotic thrombocytopenic purpura (cTTP), and pharmacokinetics (PK) characteristics of TAK-755, as well as long-term data on TAK-755 prophylaxis from a Phase 3b continuation study.ĬTTP is an ultra-rare, chronic and debilitating blood clotting disorder caused by a deficiency in ADAMTS13 enzyme.

What is the point of even having a Stash in the first place, if it completely fails at its intended purpose? So the Stash is useless and you can only use whatever items that you carry along with you, in your holding area or the Cube. This happens all the time, absolutely consistently, and this fact MUST have been obvious to the developers if they had spent so much as a few minutes playtesting the game. No matter WHAT I do - whether in Single Player or (local, TCP/IP multiplayer) - items placed in either version of the Stash, simply disappear between game sessions.

(2) Both the 'Shared' and 'Normal' stashes are basically useless. (The game crashes unpredictably, at any or all times, especially when there a lot of things happening on the screen.)

(1) Random crashes with the 'Address Violation C0000' error, particularly when moving items in the Stash. So far, the bugs in version 2.0 have made the game next to unplayable for me (and I think I have given it more than a fair chance).

Shared stash median xl 2017